Promethazine causes drowsiness and sedation in many people, along with anticholinergic side effects. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that youre taking. Meclizine belongs to a class of drugs called antihistamines. You may need to show airport staff the pharmacy label for your medication. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. hallucinations (seeing or hearing things that arent there). fast heartbeat. Brand names: Antivert, Bonine, D-Vert, Dramamine Less Drowsy, Driminate II, The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. [14] A very serious allergic reaction to this drug is unlikely, but immediate medical attention should be sought if it occurs. So, to discuss the difference between meclizine and Dramamine, I will focus on the difference between meclizineand dimenhydrinate. Medications that are currently marketed to stop the progression of dementia increase the activity of acetylcholine in the brain. What Are Dosages of Meclizine? This medicine may be used for other purposes; ask your health care provider or . Dont put this medication in your cars glove compartment or leave it in the car. Drug forms contain the racemic dihydrochloride. Meclizine also is a dopamine antagonist at D1-like and D2-like receptors[citation needed] but does not cause catalepsy[note 1] in mice, perhaps because of its anticholinergic activity. This group of medications is used to treat motion sickness, nausea, and vomiting by blocking certain brain receptors and inhibiting the transmission of certain signals to the vomiting center in the brain. This means you may need to take it with other drugs. Last medically reviewed on August 9, 2021. Phenothiazines decrease dopamine levels and depress some portions of the reticular activating system. The choice of drug, therefore, is a balance between effectiveness, side effects, and how often each is dosed. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as restlessness, confusion), fast/irregular heartbeat, shaking (tremor), difficulty urinating.Get medical help right away if you have any very serious side effects, including . [20][21], Meclizine is obtained and used as a racemate, a 1:1 mixture of the two stereoisomers. Meclizine is used for several different conditions, such as vertigo, or nausea associated with motion sickness or radiation therapy. What is the difference between meclizine and Dramamine? Dramamine is a brand name product that contains the active ingredient dimenhydrinate, which is an antihistamine. Updated 04/2022. BZDs are considered controlled substances. CINPA1 treatment does not allow CAR binding to DNA response elements at the CYP2B6 gene promoter in human hepatocytes. Bryant Ranch Prepack. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. If your doctor has prescribed this medication, take it as directed. The cookie is used to store the user consent for the cookies in the category "Analytics". Comparative studiesoften report results showing Dramamine is slightlymore effective than meclizine. It is also used to treat symptoms of vertigo (dizziness or spinning sensation) caused by disease that affects your inner ear. Feel free to send him an email at Hello@HelloPharmacist.com! Advertising revenue supports our not-for-profit mission. The most widely used medications in this class include diphenhydramine, dimenhydrinate (two of the most-studied motion-sickness drugs available in the U.S.), chlorpheniramine, meclizine, and promethazine. And combining more than one can cause too much drowsiness. Overall, both work well for motion sickness, but there are two main differences: Dramamine (dimenhydrinate) is more sedating than meclizine and is shorter-acting. Meclizine can cause a severe allergic reaction. (A) PBREM and XREM (dNR3) in the CYP2B6 promoter region. But this might not be an option if youre taking it several times a day. [9][10] Doxylamine is similarly safe. Meclizine is an antihistamine that is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. Hydroxyzine interactions with alcohol is considered a food-drug interaction. For preventing and treating motion sickness, the standard prescription dose is 25. Meclizine may interact with other medications, Important considerations for taking meclizine, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=467e464b-bbaf-4053-9136-39e47a92fa05, dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=4a5d81fc-ad25-4c3f-a91c-93fe334c02e5&type=display, Dizziness and Vertigo in Multiple Sclerosis, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, What Causes Dizziness and Fatigue? If we combine this information with your protected Feeling dizzy and tired at the same time could be a symptom of various conditions. Meclizine (meclazine) may also be prescribed for the management of vertigo (a spinning sensation or a feeling that the ground is tilted) caused by certain inner ear problems i.e. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Meclizine (Bonine) is an antihistamine. To treat vertigo, you may need to take meclizine several times daily. [7] Meclizine is sometimes combined with opioids, especially ones of the open-chain class like methadone, dextropropoxyphene, and dipipanone. And this could make driving and other activities more dangerous. Staff. Since theyre intended to help you sleep, its not too surprising that they all cause drowsiness. We comply with the HONcode standard for trustworthy health information. This might depend on your dosage and how often youre taking each medication. To find out how this drug might interact with something else youre taking, talk with your doctor or pharmacist. Centers for Disease Control and Prevention. Motion sickness. Speak to your doctor about how drug interactions should be managed. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. [1][4] In 2020, it was the 142nd most commonly prescribed medication in the United States, with more than 4million prescriptions. Meclizine. Make sure to have your current medication list handy. If you take too much: You could have dangerous levels of the drug in your body. Unlike dimenhydrinate, which is an ethanolamine, meclizine is apiperazine-derivative. Metabolism In an in vitro metabolic study using human hepatic microsome and recombinant CYP enzyme, CYP2D6 was found to be the dominant enzyme for metabolism of meclizine. Antivert is used in the treatment of vertigo; motion sickness; nausea/vomiting and belongs to the drug class anticholinergic antiemetics. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine, especially: the antidepressants bupropion, duloxetine, fluoxetine, paroxetine, or sertraline. Meclizine (meclazine) is an antihistamine with anticholinergic properties used to treat nausea, vomiting, and dizziness associated with motion sickness. Drowsiness is a common side effect. We covered first-generation antihistamines earlier when discussing sleep medications. If you are worried about being drowsy, meclizine (Dramamine Less Drowsy) may be an option to try. vomiting. It can be used for a variety of medical conditions that cause nausea and vomiting, and may be used for inner ear vertigo if related nausea is severe. Do you need underlay for laminate flooring on concrete? It may also be used for nausea after general anaesthesia or that which developed from opioid use. Mayo Clinic does not endorse companies or products. within the vestibular system which contains sensors that control your balance. health information, we will treat all of that information as protected health It shouldnt be used in people younger than 12 years. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. Allergy, Asthma and Clinical Immunology. Medically reviewed by Sanjai Sinha, MD. The controlled substances act is a legal framework that defines federal drug policy in the United States. Children 12 years of age and olderUse and dose must be determined by your doctor. Some of meclizines side effects overlap with those of BZDs. May also cause a dry mouth, a headache, tiredness, and rarely, blurred vision. For pregnant women: Meclizine is a category B pregnancy drug. You may opt-out of email communications at any time by clicking on It can be used in treating pregnancy related nausea Leathem (1986). The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Drug: Meclizine. store at controlled room temperature 20 to 25 c (68 to 77 f). We comply with the HONcode standard for trustworthy health information. 1 It is also commonly used off-label to treat an even wider variety of physical and mental health concerns . Meclizine is alsoan antihistamine but is generally less sedating. May interact with several other drugs including those that cause sedation or drugs that are also metabolized by CYP2D6 hepatic enzymes. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. StatPearls. The 12.5 mg tablets also contain: Blue 1. Meclizine may be used to treat vertigo or nausea and vomiting associated with motion sickness; however, it takes approximately an hour to start working and may cause drowsiness, although it is less likely than some other antihistamines to cause drowsiness. Meclizine is a medication used to manage and treat nausea, vomiting, and dizziness caused by motion sickness and vertigo. Most times, this is because it causes drowsiness. This content does not have an English version. If you think youre experiencing side effects from an interaction, call your healthcare provider. This medicine should not be given to a child younger than 12 years old. headache. The key ingredient of this medicine belongs to a class of anti-histamines. MECLIZINE (MEK li zeen) is an antihistamine. By providing your email address, you agree to receive emails containing coupons, refill reminders and promotional messages from GoodRx. Fig. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using. These cookies track visitors across websites and collect information to provide customized ads. May also be used to relieve symptoms of vertigo associated with diseases such as labyrinthitis and Meniere's disease.